Correction: A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice
نویسندگان
چکیده
(2008) A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med 5(1): e27. All of the other authors listed on this paper agree to this change in the authorship. We have contacted both Dr. Bhavana Solanky and Dr. Dinesh Deelchand, who have confirmed that it is appropriate for them to be listed as authors on the paper and that they have no competing interests. Three errors were made in the Funding and Acknowledgments sections of this article. In the Funding section, the " Wyeth Foundation " should be replaced by the " Centrum Foundation " and " Whitehall Robbins " should be spelled " Whitehall Robins. " In the Acknowledgments section, " Dr. Faten Al-Doori " should be spelled " Dr. Faten Al-Douri. " Copyright: © 2008 Cheung et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
منابع مشابه
A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice
BACKGROUND Stored glycogen is an important source of energy for skeletal muscle. Human genetic disorders primarily affecting skeletal muscle glycogen turnover are well-recognised, but rare. We previously reported that a frameshift/premature stop mutation in PPP1R3A, the gene encoding RGL, a key regulator of muscle glycogen metabolism, was present in 1.36% of participants from a population of wh...
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(2008) A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med 5(1): e27. All of the other authors listed on this paper agree to this change in the authorship. We have contacted both Dr. Bhavana Solanky and Dr. Dinesh Deelchand, who have confirmed that it is appropriate for them to be listed as authors on the paper and that they...
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Perspectives G lucose is the most rapidly accessible substrate in the body. Its storage as glycogen in muscle and liver is of central importance as a first source of energy for muscle contractions and prevention against hypoglycemia. Glycogen synthesis and breakdown are regulated by insulin and catecholamines as well as by glucose-6-phosphate and the amount of glycogen. There are two isoforms o...
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Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (G(M)/R(GL)) of protein phosphatase 1 (PP1) causes substantial lowering of the glycogen synthase activity and a 10-fold decrease in the glycogen levels in skeletal muscle. Homozygous G(M)(-/-) mice show increased weight gain after 3 months of age and become obese, weighing approximately 20% more than their wild-type (WT) lit...
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ورودعنوان ژورنال:
- PLoS Medicine
دوره 5 شماره
صفحات -
تاریخ انتشار 2008